Tehran - Afkar News:San Diego State University researchers at the Donald P. Shiley BioScience Center may have found the secret to helping the immune system fight off the flu before it gets you sick,Science Dailyreported.
A new study published July ۶ in the Public Library of Science journal PLoS ONE, finds that EP۶۷, a powerful synthetic protein, is able to activate the innate immune system within just two hours of being administered.
Prior to this study, EP۶۷ had been primarily used as an adjuvant for vaccines, something added to the vaccine to help activate the immune response. But Joy Phillips, Ph. D. a lead author of the study with her colleague Sam Sanderson, Ph. D. at the University of Nebraska Medical Center, saw potential for it to work on its own.
" The flu virus is very sneaky and actively keeps the immune system from detecting it for a few days until you are getting symptoms, " Phillips said. " Our research showed that by introducing EP۶۷ into the body within ۲۴ hours of exposure to the flu virus caused the immune system to react almost immediately to the threat, well before your body normally would. "
Because EP۶۷ doesn ' t work on the virus but on the immune system itself, it functions the same no matter the flu strain, unlike the influenza vaccine which has to exactly match the currently circulating strain.
Phillips said while this study focuses on the flu, EP۶۷ has the potential to work on other respiratory diseases and fungal infections and could have huge potential for emergency therapeutics.
" When you find out you ' ve been exposed to the flu, the only treatments available now target the virus directly but they are not reliable and often the virus develops a resistance against them, " Phillips said. " EP۶۷ could potentially be a therapeutic that someone would take when they know they ' ve been exposed that would help the body fight off the virus before you get sick. "
It could even be used in the event of a new strain of infectious disease, before the actual pathogen has been identified, as in SARS or the ۲۰۰۹ H۱N۱ influenza outbreak, Phillips said.
Right now, the testing has been done primarily in mice by infecting them with a flu virus. Those that were given a dose of EP۶۷ within ۲۴ hours of the infection didn ' t get sick(or as sick) as those that were not treated with EP۶۷.
The level of illness in mice is measured by weight loss. Typically, mice lose approximately ۲۰ percent of their weight when they are infected with the flu but mice treated with EP۶۷ lost an average of just six percent. More importantly, mice who were treated a day after being infected with a lethal dose of influenza did not die, Phillips said.
She said there are also huge implications for veterinary applications, since EP۶۷ is active in animals, including birds.
Future research will examine the effect EP۶۷ has in the presence of a number of other pathogens and to look closer at exactly how EP۶۷ functions within different cells in the body
